STT3B Gene Summary [Human]
The protein encoded by this gene is a catalytic subunit of a protein complex that transfers oligosaccharides onto asparagine residues. Defects in this gene are a cause of congenital disorder of glycosylation Ix (CDG1X). [provided by RefSeq, Jun 2014]
Details
| Type | Processed Transcript |
| Official Symbol | STT3B |
| Official Name | STT3 oligosaccharyltransferase complex catalytic subunit B [Source:HGNC Symbol;Acc:HGNC:30611] |
| Ensembl ID | ENSG00000163527 |
| Bio databases IDs | |
| Aliases | STT3 oligosaccharyltransferase complex catalytic subunit B, source of immunodominant MHC associated peptides, dolichyl-diphosphooligosaccharide protein glycotransferase, Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B |
| Synonyms | 1300006C19Rik, CDG1X, LOC105377020, RGD1311563, SIMP, STT3 oligosaccharyltransferase complex catalytic subunit B, STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STT3B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dolichyl-diphosphooligosaccharide-protein glycotransferase
- Oligosaccharyl transferase STT3 subunit
- enzyme
- protein binding
- dolichyl-phosphate-mannose-protein mannosyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of glycosylation type 1x
role in cell
- cell viability
- proliferation
- glycosylation in
- aggregation in
- N-glycosylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STT3B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein catabolic process
- protein N-linked glycosylation
- protein N-linked glycosylation via asparagine
- co-translational protein modification
- response to unfolded protein
- post-translational protein modification
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- oligosaccharyltransferase complex
- membrane
- macromolecular complex
- endoplasmic reticulum
- oligosaccharyltransferase I complex
Molecular Function
What the gene product does at the molecular level
- dolichyl-diphosphooligosaccharide-protein glycotransferase activity
- protein binding
- metal ion binding