TAAR1 Gene Summary [Human]
The protein encoded by this gene is a G-protein coupled receptor activated by trace amines. The encoded protein responds little or not at all to dopamine, serotonin, epinephrine, or histamine, but responds well to beta-phenylethylamine, p-tyramine, octopamine, and tryptamine. While primarily functioning in neurologic systems, there is evidence that this gene is involved in blood cell and immunologic functions as well. This gene is thought to be intronless. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | TAAR1 |
| Official Name | trace amine associated receptor 1 [Source:HGNC Symbol;Acc:HGNC:17734] |
| Ensembl ID | ENSG00000146399 |
| Bio databases IDs | |
| Aliases | trace amine associated receptor 1 |
| Synonyms | TA1, TAR1, trace-amine-associated receptor 1, TRAR1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAAR1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- trace-amine receptor
- amine receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the TAAR1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dyskinesia
- neoplasia
- attention deficit hyperactivity disorder
- narcolepsy
- cocaine dependence
- human immunodeficiency virus I infection
- conduct disorder
- attention deficit disorder
- obesity
- methamphetamine dependence
regulated by
- 2-phenethylamine
- amphetamine
- CFTR
- dopamine
- methamphetamine
- tyramine
- octopamine
- 5-hydroxytryptamine
- 3-iodothyronamine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- endomembrane system
- intracellular compartment
- intracellular space
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAAR1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- trace-amine receptor activity