Taar1 Gene Summary [Mouse]
Enables trace-amine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and phospholipase C-activating G protein-coupled receptor signaling pathway. Acts upstream of or within G protein-coupled receptor signaling pathway. Is active in plasma membrane. Used to study schizophrenia. Orthologous to human TAAR1 (trace amine associated receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taar1 |
| Official Name | trace amine-associated receptor 1 [Source:MGI Symbol;Acc:MGI:2148258] |
| Ensembl ID | ENSMUSG00000056379 |
| Bio databases IDs | |
| Aliases | trace amine-associated receptor 1 |
| Synonyms | TA1, TAR1, trace-amine-associated receptor 1, TRAR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taar1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- trace-amine receptor
- amine receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Taar1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dyskinesia
- neoplasia
- attention deficit hyperactivity disorder
- narcolepsy
- cocaine dependence
- human immunodeficiency virus I infection
- conduct disorder
- attention deficit disorder
- obesity
- methamphetamine dependence
regulated by
- 2-phenethylamine
- amphetamine
- CFTR
- dopamine
- methamphetamine
- tyramine
- octopamine
- 5-hydroxytryptamine
- 3-iodothyronamine
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- endomembrane system
- intracellular compartment
- intracellular space
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taar1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- trace-amine receptor activity