ASB15 Gene Summary [Human]
This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Details
| Type | Protein Coding |
| Official Symbol | ASB15 |
| Official Name | ankyrin repeat and SOCS box containing 15 [Source:HGNC Symbol;Acc:HGNC:19767] |
| Ensembl ID | ENSG00000146809 |
| Bio databases IDs | |
| Aliases | ankyrin repeat and SOCS box containing 15 |
| Synonyms | 4930400E23Rik, ankyrin repeat and SOCS box-containing 15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ASB15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SOCS box
- transcription regulator
- Ankyrin repeats (many copies)
- Ankyrin repeats (3 copies)
- SOCS
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ASB15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- Golgi to lysosome transport
- retrograde transport, endosome to Golgi
- intracellular signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosol
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding