MEPCE Gene Summary [Human]
Enables 7SK snRNA binding activity and RNA 5'-methyltransferase activity. Involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Located in nucleus. Part of 7SK snRNP. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Retained Intron |
| Official Symbol | MEPCE |
| Official Name | methylphosphate capping enzyme [Source:HGNC Symbol;Acc:HGNC:20247] |
| Ensembl ID | ENSG00000146834 |
| Bio databases IDs | |
| Aliases | methylphosphate capping enzyme |
| Synonyms | BCDIN3, D5Wsu46e, FLJ20257, LOC100910540, methylphosphate capping enzyme |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MEPCE often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- O-methyltransferase
- snRNA binding
- RNA methyltransferase
- Bicoid-interacting protein 3 (Bin3)
- enzyme
- protein binding
- AdoMet_MTases
- S-adenosylmethionine-dependent methyltransferase
- methyltransferase domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MEPCE gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- RNA methylation
- positive regulation of G1/S transition of mitotic cell cycle
- snRNA metabolic process
- snRNA modification
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- RNA methyltransferase activity
- O-methyltransferase activity
- protein binding
- RNA binding
- snRNA binding
- S-adenosylmethionine-dependent methyltransferase activity