FATE1 Gene Summary [Human]
This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | FATE1 |
| Official Name | fetal and adult testis expressed 1 [Source:HGNC Symbol;Acc:HGNC:24683] |
| Ensembl ID | ENSG00000147378 |
| Bio databases IDs | |
| Aliases | fetal and adult testis expressed 1, cancer/testis antigen 43 |
| Synonyms | CT43, FATE, fetal and adult testis expressed 1, foetal and adult testis expressed 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FATE1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- Endoplasmic Reticulum
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FATE1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reduction of mitochondrial calcium ion concentration
- negative regulation of apoptotic process
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- ER-mitochondrion membrane contact site
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ubiquitin protein ligase binding