TMEM74 Gene Summary [Human]
Involved in macroautophagy. Predicted to be located in autophagosome membrane; cytoplasmic vesicle; and lysosomal membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | TMEM74 |
| Official Name | transmembrane protein 74 [Source:HGNC Symbol;Acc:HGNC:26409] |
| Ensembl ID | ENSG00000164841 |
| Bio databases IDs | |
| Aliases | transmembrane protein 74 |
| Synonyms | B230382K22Rik, NET36, RGD1566279, transmembrane protein 74 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMEM74 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ion channel binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMEM74 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- general adaptation syndrome, behavioral process
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle
- lysosomal membrane
- plasma membrane
- autophagic vacuole membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ion channel binding