MARCHF5 Gene Summary [Human]
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | MARCHF5 |
| Official Name | membrane associated ring-CH-type finger 5 [Source:HGNC Symbol;Acc:HGNC:26025] |
| Ensembl ID | ENSG00000198060 |
| Bio databases IDs | |
| Aliases | membrane associated ring-CH-type finger 5, mitochondrial ubiquitin ligase |
| Synonyms | 1810015H18RIK, 2310008I22Rik, 2700055A20Rik, 5730499H23RIK, E130202O05Rik, FLJ20445, MARCH5, MARCH-V, membrane associated ring-CH-type finger 5, MITOL, RNF153 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MARCHF5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- enzyme binding
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
role in cell
- generation in
- formation in
- expression in
- production in
- cell death
- apoptosis
- accumulation in
- degradation in
- ubiquitination in
- fragmentation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MARCHF5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization in mitochondrion
- protein polyubiquitination
- regulation of mitochondrial fission
- positive regulation of mitochondrial fission
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrion
- membrane
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- GTPase binding