MRRF Gene Summary [Human]
This gene encodes a ribosome recycling factor, which is a component of the mitochondrial translational machinery. The encoded protein, along with mitochondrial elongation factor 2, functions in ribosomal recycling at the termination of mitochondrial translation by mediating the disassembly of ribosomes from messenger RNA. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | MRRF |
| Official Name | mitochondrial ribosome recycling factor [Source:HGNC Symbol;Acc:HGNC:7234] |
| Ensembl ID | ENSG00000148187 |
| Bio databases IDs | |
| Aliases | mitochondrial ribosome recycling factor |
| Synonyms | 2400002D02RIK, mitochondrial ribosome recycling factor, MRFF, MTRRF, RRF |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MRRF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RRF
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MRRF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ribosome disassembly
- translation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribosomal large subunit binding