IDI2 Gene Summary [Human]
The protein encoded by this gene catalyzes the conversion of isopentenyl diphosphate to dimethylallyl diphosphate, which is a precursor for the synthesis of cholesterol and other isoprenoids. This gene, which is a product of an ancestral gene duplication event, encodes a protein that may be involved in the aggregation of alpha-synuclein in the cerebral cortex of patients with Lewy body disease. In addition, segmental copy number gains in this locus have been associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Jul 2016]
Details
| Type | Protein Coding |
| Official Symbol | IDI2 |
| Official Name | isopentenyl-diphosphate delta isomerase 2 [Source:HGNC Symbol;Acc:HGNC:23487] |
| Ensembl ID | ENSG00000148377 |
| Bio databases IDs | |
| Aliases | isopentenyl-diphosphate delta isomerase 2 |
| Synonyms | IPPI2, IPP isomerase 2, isopentenyl-diphosphate delta isomerase 2, isopentenyl-diphosphate δ isomerase 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IDI2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- isopentenyl-diphosphate delta-isomerase, type 1
- isopentenyl-diphosphate D-isomerase
- enzyme
- protein binding
- NUDIX hydrolase superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IDI2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- isopentenyl diphosphate biosynthetic process
- dimethylallyl diphosphate biosynthetic process
- cholesterol biosynthetic process
- isoprenoid biosynthetic process
- isopentenyl diphosphate metabolic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- cytoplasm
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- isopentenyl-diphosphate delta-isomerase activity