RNF114 Gene Summary [Human]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Located in cytosol and plasma membrane. Biomarker of male infertility. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | RNF114 |
| Official Name | ring finger protein 114 [Source:HGNC Symbol;Acc:HGNC:13094] |
| Ensembl ID | ENSG00000124226 |
| Bio databases IDs | |
| Aliases | ring finger protein 114 |
| Synonyms | 1110008J21Rik, PSORS12, ring finger protein 114, Zfp228, Zfp313, ZNF228, ZNF313 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF114 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Drought induced 19 protein (Di19), zinc-binding
- C2HC Zing finger domain
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Ring finger domain
- protein binding
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- coronary artery disease
- frontotemporal dementia
role in cell
- degradation in
- migration
- K27 polyubiquitination in
- trapping in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Plasma Membrane
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF114 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
- spermatogenesis
- cell differentiation
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding