DNAJB8 Gene Summary [Human]
The protein encoded by this gene belongs to the DNAJ/HSP40 family of proteins that regulate chaperone activity. This family member suppresses aggregation and toxicity of polyglutamine proteins, and the C-terminal tail is essential for this activity. It has been implicated as a cancer-testis antigen and as a cancer stem-like cell antigen involved in renal cell carcinoma. [provided by RefSeq, Jun 2012]
Details
| Type | Protein Coding |
| Official Symbol | DNAJB8 |
| Official Name | DnaJ heat shock protein family (Hsp40) member B8 [Source:HGNC Symbol;Acc:HGNC:23699] |
| Ensembl ID | ENSG00000179407 |
| Bio databases IDs | |
| Aliases | DnaJ heat shock protein family (Hsp40) member B8 |
| Synonyms | 1700016F14Rik, 1700031F10Rik, CT156, DJ6, DnaJ heat shock protein family (Hsp40) member B8, mDj6, MGC33884, RGD1561981 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DNAJB8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DnaJ domain
- DnaJ
- DnaJ molecular chaperone homology domain
- Ubl1_cv_Nsp3_N-like
- protein binding
- chaperone binding
Pathways
Biological processes and signaling networks where the DNAJB8 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DNAJB8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone-mediated protein folding
- negative regulation of inclusion body assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding involved in protein folding
- chaperone binding
- unfolded protein binding
- Hsp70 protein binding