NACC2 Gene Summary [Human]
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle by negative regulation of transcription from RNA polymerase II promoter; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein homooligomerization. Located in chromatin; mitochondrion; and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | NACC2 |
| Official Name | NACC family member 2 [Source:HGNC Symbol;Acc:HGNC:23846] |
| Ensembl ID | ENSG00000148411 |
| Bio databases IDs | |
| Aliases | NACC family member 2, BEN domain containing 9 |
| Synonyms | 0610020I02RIK, BEND9, BTBD14, BTBD14A, BTBD31, C030048H19RIK, LOC100509476, NAC-2, NACC family member 2, nucleus accumbens associated 2, BEN and BTB (POZ) domain containing, RBB |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NACC2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- nucleic acid binding
- BTB_POZ
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- binding protein
- The BEN domain is found in diverse animal proteins
- double-stranded DNA binding
- Broad-Complex, Tramtrack and Bric a brac
- protein homodimerization
- BTB/POZ domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Sjögren syndrome
role in cell
- expression in
- apoptosis
- proliferation
- stabilization in
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NACC2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- protein complex localization
- negative regulation of transcription, DNA-dependent
- negative regulation of cell proliferation
- protein homooligomerization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrion
- nucleolus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- histone deacetylase binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity