FEM1A Gene Summary [Human]
Enables EP4 subtype prostaglandin E2 receptor binding activity and ubiquitin ligase-substrate adaptor activity. Involved in negative regulation of inflammatory response and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul2-RING ubiquitin ligase complex. Is active in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FEM1A |
| Official Name | fem-1 homolog A [Source:HGNC Symbol;Acc:HGNC:16934] |
| Ensembl ID | ENSG00000141965 |
| Bio databases IDs | |
| Aliases | fem-1 homolog A |
| Synonyms | AC0055232, EPRAP, Fem1aa, fem-1 homolog A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FEM1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Ankyrin repeats (many copies)
- protein binding activity, bridging
- G-protein-coupled receptor binding
- Ankyrin repeats (3 copies)
- transcription factor binding
- protein binding
- Ankyrin repeat
- ankyrin repeats
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FEM1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- positive regulation of inflammatory response
- regulation of ubiquitin-protein ligase activity
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- ubiquitin ligase complex
- mitochondrion
- cytosol
- Cul2-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- EP4 subtype prostaglandin E2 receptor binding
- protein binding