DGKZ Gene Summary [Human]
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | DGKZ |
| Official Name | diacylglycerol kinase zeta [Source:HGNC Symbol;Acc:HGNC:2857] |
| Ensembl ID | ENSG00000149091 |
| Bio databases IDs | |
| Aliases | diacylglycerol kinase zeta |
| Synonyms | 80-kDa Dg Kinase, DAGK5, DAGK6, Dgk4, DGK-ZETA, DGK-ζ, Diacylglycerol kinase, diacylglycerol kinase zeta, diacylglycerol kinase ζ, E130307B02Rik, F730209L11Rik, hDGKzeta, KDGZ, mDGK[z] |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DGKZ often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- lipid kinase
- diacylglycerol kinase
- catalytic domain
- nuclear localization sequence
- enzyme inhibitor activity
- ATP binding
- C1A domain
- Ankyrin repeats (3 copies)
- myristoylated alanine-rich protein kinase C substrate-phophorylation site domain
- protein binding
- Diacylglycerol kinase catalytic domain (presumed)
- kinase
- MARCKS domain
- Diacylglycerol kinase accessory domain
- protein kinase C conserved region 1 (C1 domain) superfamily
- C1B domain
- Diacylglycerol kinase catalytic domain
- PDZ binding motif
Pathways
Biological processes and signaling networks where the DGKZ gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- acute myeloid leukemia
- passive cutaneous anaphylaxis
- primary cancer
- organismal death
- primary central nervous system lymphoma
- lymphomagenesis
- central nervous system cancer
- metastasis
- non-melanoma skin cancer
role in cell
- number
- maturation
- phosphorylation in
- production in
- quantity
- binding in
- activation in
- proliferation
- differentiation
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- glutaminergic synapse
- cell periphery
- somatodendritic region
- cellular membrane
- Nucleus
- Plasma Membrane
- cytoplasmic aggregates
- cytosol
- membrane ruffles
- nuclear speckles
- neuromuscular junctions
- synapse
- sarcolemma
- cell membrane leading edge
- perikaryon
- dendrites
- postsynaptic density
- lamellipodia
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DGKZ gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell receptor signaling pathway
- glycerolipid metabolic process
- protein kinase C-activating G-protein coupled receptor signaling pathway
- cell migration
- platelet activation
- intracellular signal transduction
- diacylglycerol metabolic process
- lipid phosphorylation
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- membrane
- cytosol
- plasma membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- diacylglycerol kinase activity
- kinase activity
- alkylglycerol kinase activity