CHRM1 Gene Summary [Human]
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CHRM1 |
| Official Name | cholinergic receptor muscarinic 1 [Source:HGNC Symbol;Acc:HGNC:1950] |
| Ensembl ID | ENSG00000168539 |
| Bio databases IDs | |
| Aliases | cholinergic receptor muscarinic 1, acetylcholine receptor, muscarinic 1 |
| Synonyms | Achr, cholinergic receptor muscarinic 1, cholinergic receptor, muscarinic 1, cholinergic receptor, muscarinic 1, CNS, HM1, M1, M1 MUSCARINIC receptor, M1R |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHRM1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled acetylcholine receptor
- intracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- ion channel
Pathways
Biological processes and signaling networks where the CHRM1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- cancer
- migraines
- nausea
- headache
- acute mountain sickness
- vomiting
- postoperative nausea and vomiting
- chemotherapy sickness
- psychosis
role in cell
- proliferation
- apoptosis
- activation in
- mitochondrial respiration in
- formation
- molecular cleavage in
- ruffling
- phosphorylation in
- activation
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- glutaminergic synapse
- cellular membrane
- presynaptic membrane
- postsynaptic membrane
- synaptic membrane
- neurites
- synapse
- perikaryon
- dendrites
- axon terminals
- postsynaptic terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHRM1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of intracellular protein transport
- regulation of postsynaptic membrane potential
- adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway
- G-protein coupled receptor signaling pathway
- regulation of locomotion
- neuromuscular synaptic transmission
- signal transduction
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- regulation of glial cell proliferation
- nervous system development
- G-protein coupled acetylcholine receptor signaling pathway
- synaptic transmission
- protein kinase C-activating G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway
- positive regulation of ion transport
- cognition
- saliva secretion
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- dendrite
- membrane
- synapse
- plasma membrane
- axon terminus
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- G-protein coupled acetylcholine receptor activity
- serotonin receptor activity