ZP1 Gene Summary [Human]
The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene ensures the structural integrity of the zona pellucida. Mutations in this gene are a cause of oocyte maturation defect and infertility. [provided by RefSeq, May 2014]
Details
| Type | Protein Coding |
| Official Symbol | ZP1 |
| Official Name | zona pellucida glycoprotein 1 [Source:HGNC Symbol;Acc:HGNC:13187] |
| Ensembl ID | ENSG00000149506 |
| Bio databases IDs | |
| Aliases | zona pellucida glycoprotein 1 |
| Synonyms | HEL163, MGC87693, OOMD, OOMD1, OZEMA1, zona pellucida glycoprotein 1, ZP1-202, ZPB1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zona pellucida-like domain
- Zona pellucida (ZP) domain
- extracellular matrix structural constituent
- protein binding
- Trefoil
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- intracellular space
- cellular membrane
- Golgi Apparatus
- zona pellucida
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- binding of sperm to zona pellucida
- prevention of polyspermy
Cellular Component
Where in the cell the gene product is active
- egg coat
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of egg coat
- acrosin binding