RASGRF2 Gene Summary [Human]
RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]
Details
| Type | Protein Coding |
| Official Symbol | RASGRF2 |
| Official Name | Ras protein specific guanine nucleotide releasing factor 2 [Source:HGNC Symbol;Acc:HGNC:9876] |
| Ensembl ID | ENSG00000113319 |
| Bio databases IDs | |
| Aliases | Ras protein specific guanine nucleotide releasing factor 2 |
| Synonyms | 6330417G04RIK, GRF2, GRP2, RAS protein-specific guanine nucleotide-releasing factor 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RASGRF2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGEF
- guanyl-nucleotide exchange factor
- IQ domain
- PH domain
- protein binding
- RasGEF
- Cdc25 domain
- Pleckstrin homology-like domain
- Dbl homology domain
- RhoGEF domain
Pathways
Biological processes and signaling networks where the RASGRF2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- eating disorder
- pancreatic cancer
- refractive error
- neoplastic cell transformation
- ischemic injury
- insomnia
- colorectal mucinous adenocarcinoma
- colorectal carcinomagenesis
- ductal breast carcinoma
role in cell
- growth
- proliferation
- phosphorylation in
- morphology
- activation in
- function
- damage
- blast transformation
- cell-cell contact
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- postsynaptic region
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- perinuclear space
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RASGRF2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- long-term synaptic potentiation
- Ras protein signal transduction
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- cytosol
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calmodulin binding
- guanyl-nucleotide exchange factor activity