BDKRB2 Gene Summary [Human]
This gene encodes a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. Bradykinin is released upon activation by pathophysiologic conditions such as trauma and inflammation, and binds to its kinin receptors, B1 and B2. The B2 receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. [provided by RefSeq, Apr 2020]
Details
| Type | Protein Coding |
| Official Symbol | BDKRB2 |
| Official Name | bradykinin receptor B2 [Source:HGNC Symbol;Acc:HGNC:1030] |
| Ensembl ID | ENSG00000168398 |
| Bio databases IDs | |
| Aliases | bradykinin receptor B2 |
| Synonyms | B2, B(2), B2BKR, B2BRA, B2R, B2 receptor, BK-2, BK2R, Bkb2, BKR2, BRADYKININ B2 receptor, bradykinin receptor B2, bradykinin receptor, beta 2, bradykinin receptor, β 2, BRB2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BDKRB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- Cholecystokinin A receptor, N-terminal
- protease binding
- G-protein-coupled receptor binding
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- immunoreceptor tyrosine-based inhibition motif
- transmembrane domain
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
- bradykinin receptor
- protein heterodimerization
Pathways
Biological processes and signaling networks where the BDKRB2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- cancer
- albuminuria
- neoplasia
- fibrosis
- shock response
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- diffuse mesangial sclerosis
- prostate cancer
role in cell
- migration
- apoptosis
- phosphorylation in
- proliferation
- production in
- chemotaxis
- activation in
- inhibition in
- formation
- sprouting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- cell borders
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- Golgi Apparatus
- cytoplasmic aggregates
- membrane rafts
- cell membrane leading edge
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BDKRB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to salt stress
- G-protein coupled receptor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- blood circulation
- regulation of vascular permeability
- vasoconstriction
- cell surface receptor signaling pathway
- vasodilation
- elevation of cytosolic calcium ion concentration
- inflammatory response
- arachidonic acid secretion
- smooth muscle contraction
- negative regulation of peptidyl-serine phosphorylation
- regulation of vasoconstriction
Cellular Component
Where in the cell the gene product is active
- endosome
- intracellular membrane-bounded organelle
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol phospholipase C activity
- protein binding
- type 1 angiotensin receptor binding
- protein heterodimerization activity
- bradykinin receptor activity
- protease binding