USP43 Gene Summary [Human]

Predicted to enable ISG15-specific protease activity. Predicted to be involved in translesion synthesis. Predicted to be located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Processed Transcript
Official Symbol
USP43
Official Name
ubiquitin specific peptidase 43 [Source:HGNC Symbol;Acc:HGNC:20072]
Ensembl ID
ENSG00000154914
Bio databases IDs NCBI: 124739 Ensembl: ENSG00000154914
Aliases ubiquitin specific peptidase 43
Synonyms C630032K07RIK, ubiquitin specific peptidase 43
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP43 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ISG15-specific protease
  • peptidase

Pathways

Biological processes and signaling networks where the USP43 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • metastasis
  • dementia
  • coronary artery disease
  • myopia
regulates
  • AR
  • CTTN
  • NFkB (complex)
  • IKK (complex)
role in cell
  • expression in
  • formation
  • activation in
  • formation in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human USP43 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • proteolysis
  • translesion synthesis

Cellular Component

Where in the cell the gene product is active
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • ubiquitin-specific protease activity
  • ISG15-specific protease activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.