INTS1 Gene Summary [Human]
INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | INTS1 |
| Official Name | integrator complex subunit 1 [Source:HGNC Symbol;Acc:HGNC:24555] |
| Ensembl ID | ENSG00000164880 |
| Bio databases IDs | |
| Aliases | integrator complex subunit 1 |
| Synonyms | 1110015K06Rik, INT1, integrator complex subunit 1, LOC100365889, LOC103689975, NDCAGF, NET28, RGD1308908 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human INTS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein of unknown function (DUF3677)
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INTS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snRNA processing
- U2 snRNA 3'-end processing
- inner cell mass cell proliferation
- regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of apoptotic process
- embryo implantation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- membrane
- nucleoplasm
- integrator complex