MBD3
MBD3 Gene Summary
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. This gene belongs to a family of nuclear proteins which are characterized by the presence of a methyl-CpG binding domain (MBD). The encoded protein is a subunit of the NuRD, a multisubunit complex containing nucleosome remodeling and histone deacetylase activities. Unlike the other family members, the encoded protein is not capable of binding to methylated DNA. The protein mediates the association of metastasis-associated protein 2 with the core histone deacetylase complex. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | MBD3 |
| Official Name | methyl-CpG binding domain protein 3 [Source:HGNC Symbol;Acc:HGNC:6918] |
| Ensembl ID | ENSG00000071655 |
| Bio databases IDs | |
| Aliases | methyl-CpG binding domain protein 3 |
| Synonyms | methyl-CpG binding domain protein 3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- methyl-CpG binding
- p55-binding region of Methyl-CpG-binding domain proteins MBD
- coiled-coil domain
- protein binding
- MBD
- C-terminal domain of methyl-CpG binding protein 2 and 3
- DNA binding
Pathways
Biological processes and signaling networks where the MBD3 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ZNF219
- H2BC21
- MAD2L1
- GATA4
- EP300
- MTA1/2
- JARID2
- SERTAD3
- CUL4B
- BIRC3
disease
- hyperplasia
- neoplasia
- liver cancer
- epithelial cancer
- prostate cancer
- rectal adenocarcinoma
- colorectal carcinomagenesis
- rectum cancer
- gastric cancer
- breast carcinoma
regulated by
- FIRRE
- RUNX1
- AURKA
- CDK2AP1
- POLD3
- MBD2
- CHD4
- triclosan
- MYC
- JUN
regulates
- JUN
- AKT
- CCND1
- CTNNB1
- ACTA2
- PI3K (family)
- MTOR
- YAF2
- LGR5
- ACTC1
role in cell
- proliferation
- migration
- expression in
- differentiation
- phosphorylation in
- growth
- invasion by
- colony formation by
- remodeling
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- heterochromatin
- Cytoplasm
- centrosome
- nuclear foci
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MBD3 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- regulation of cell fate specification
- embryonic organ development
- methylation-dependent chromatin silencing
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- ventricular cardiac muscle tissue development
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
- response to estradiol stimulus
- response to nutrient levels
CELLULAR COMPONENT
Where in the cell the gene product is active
- heterochromatin
- nucleus
- cytoplasm
- NuRD complex
- macromolecular complex
- chromatin
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- DNA binding
- protein binding
- nucleosomal DNA binding
- methyl-CpG binding