YWHAB Gene Summary [Human]
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | YWHAB |
| Official Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [Source:HGNC Symbol;Acc:HGNC:12849] |
| Ensembl ID | ENSG00000166913 |
| Bio databases IDs | |
| Aliases | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta, 14-3-3 beta, 14-3-3 alpha |
| Synonyms | 1300003C17Rik, 14-3-3 Alpha, 14-3-3b, 14-3-3 beta, 14-3-3 beta/alpha, 14-3-3 α, 14-3-3 β, 14-3-3 β/α, GW128, HEL-S-1, HS1, KCIP-1, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein β, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, β, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, β polypeptide, YWHAA |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YWHAB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dimerization domain
- 14-3-3 domain
- protein kinase inhibitor activity
- enzyme binding
- phosphoprotein binding
- histone deacetylase binding
- protein domain specific binding
- protein binding
- identical protein binding
- phosphoprotein amino acid binding
- protein phosphatase inhibitor activity
- binding protein
- 14-3-3 protein
Pathways
Biological processes and signaling networks where the YWHAB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- psoriasis
- malignant neoplasm of esophagus
- esophageal cancer
- astrocytoma
- glioma formation
- schizophrenia
- Rett syndrome
- colorectal neoplasm
- colorectal neoplasia
role in cell
- apoptosis
- proliferation
- cell cycle progression
- upregulation in
- degradation in
- silencing in
- transcription in
- sphere formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- perinuclear region
- Nucleus
- lipid droplets
- cytosol
- Golgi membrane
- nucleoplasm
- neurites
- Z line
- perikaryon
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YWHAB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- cytoplasmic sequestering of protein
- signal transduction
- positive regulation of catalytic activity
- protein localization
- negative regulation of protein dephosphorylation
- negative regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- focal adhesion
- cytoplasm
- melanosome
- membrane
- cytosol
- vacuolar membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- protein binding
- histone deacetylase binding
- cadherin binding
- phosphoserine binding
- phosphoprotein binding
- protein kinase inhibitor activity
- enzyme binding