ERO1B Gene Summary [Human]
Enables thiol oxidase activity. Involved in protein folding in endoplasmic reticulum. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ERO1B |
| Official Name | endoplasmic reticulum oxidoreductase 1 beta [Source:HGNC Symbol;Acc:HGNC:14355] |
| Ensembl ID | ENSG00000086619 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum oxidoreductase 1 beta |
| Synonyms | 1300013B24RIK, 1700065B09Rik, AI447560, endoplasmic reticulum oxidoreductase 1 beta, endoplasmic reticulum oxidoreductase 1 β, Ero1beta, ERO1LB, ERO1-Lbeta, ERO1-Lβ, ERO1-L(β), ero1-β, LOC108353430, RGD1563548 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ERO1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- disulfide oxidoreductase
- thiol oxidase
- protein disulfide oxidoreductase
- enzyme
- protein binding
- Endoplasmic Reticulum Oxidoreductin 1 (ERO1)
Pathways
Biological processes and signaling networks where the ERO1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ERO1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin processing
- protein folding
- protein folding in endoplasmic reticulum
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum lumen
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- FAD binding
- protein binding
- protein disulfide oxidoreductase activity
- oxidoreductase activity
- unfolded protein binding
- thiol oxidase activity