KDM8 Gene Summary [Human]
This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | KDM8 |
| Official Name | lysine demethylase 8 [Source:HGNC Symbol;Acc:HGNC:25840] |
| Ensembl ID | ENSG00000155666 |
| Bio databases IDs | |
| Aliases | lysine demethylase 8, JmjC arginyl-hydroxylase |
| Synonyms | 3110005O21Rik, FLJ13798, JMJD5, lysine demethylase 8, lysine (K)-specific demethylase 8, RGD1304823 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KDM8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- endopeptidase
- 2-oxoglutarate:oxygen oxidoreductase
- aminopeptidase
- chromatin binding
- enzyme
- p53 binding
- protein binding
- JmjC domain
- histone demethylase activity
- Cupin-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- growth failure
role in cell
- expression in
- proliferation
- transcription in
- production in
- cell cycle progression
- formation
- glycolysis in
- transactivation in
- recruitment in
- tetramerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KDM8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein destabilization
- fibroblast proliferation
- circadian regulation of gene expression
- chromatin remodeling
- G2/M transition of mitotic cell cycle
- negative regulation of transcription, DNA-dependent
- in utero embryonic development
- positive regulation of transcription, DNA-dependent
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding
- metal ion binding
- methylated histone residue binding
- endopeptidase activity
- aminopeptidase activity
- chromatin binding
- histone demethylase activity (H3-K36 specific)