CD70 Gene Summary [Human]
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CD70 |
| Official Name | CD70 molecule [Source:HGNC Symbol;Acc:HGNC:11937] |
| Ensembl ID | ENSG00000125726 |
| Bio databases IDs | |
| Aliases | CD70 molecule |
| Synonyms | CD27-L, CD27LG, CD70 antigen, CD70 molecule, LPFS3, TNFSF7, TNLG8A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CD70 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- TNF homology domain
- TNF
- receptor agonist activity
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the CD70 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- asthma
- neoplasia
- hydronephrosis
- systemic lupus erythematosus
- non-Hodgkin lymphoma
- non-Hodgkin disease
- collagen-induced arthritis
- anemia
- head and neck squamous cell carcinoma
role in cell
- production in
- quantity
- expression in
- apoptosis
- number
- killing
- activation
- binding in
- proliferation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell surface
- cellular membrane
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CD70 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- T cell mediated immunity
- tumor necrosis factor-mediated signaling pathway
- extrinsic apoptotic signaling pathway
- T cell activation
- B cell proliferation
- cell surface receptor signaling pathway
- positive regulation of T cell proliferation
- B cell mediated immunity
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor receptor binding
- receptor agonist activity