SLFN11 Gene Summary [Human]
Enables tRNA binding activity. Involved in several processes, including defense response to virus; negative regulation of G1/S transition of mitotic cell cycle; and replication fork arrest. Located in cytosol; nucleoplasm; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLFN11 |
| Official Name | schlafen family member 11 [Source:HGNC Symbol;Acc:HGNC:26633] |
| Ensembl ID | ENSG00000172716 |
| Bio databases IDs | |
| Aliases | schlafen family member 11 |
| Synonyms | schlafen family member 11, SLFN8/9 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLFN11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tRNA binding
- Putative DNA-binding domain
- enzyme
- protein binding
- ATPase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
- survival
- Moyamoya disease
role in cell
- binding in
- quantity
- survival
- apoptosis
- growth
- cell viability
- molecular cleavage in
- phosphorylation in
- cell cycle progression
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLFN11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- replication fork arrest
- defense response to virus
- negative regulation of G1/S transition of mitotic cell cycle
- negative regulation of DNA replication
- response to DNA damage stimulus
- immune system process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- DNA binding
- protein binding
- endonuclease activity
- helicase activity
- tRNA binding