SAXO1 Gene Summary [Human]
Enables microtubule binding activity. Involved in several processes, including cold acclimation; positive regulation of cilium assembly; and protein stabilization. Located in microtubule cytoskeleton and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SAXO1 |
| Official Name | stabilizer of axonemal microtubules 1 [Source:HGNC Symbol;Acc:HGNC:28566] |
| Ensembl ID | ENSG00000155875 |
| Bio databases IDs | |
| Aliases | stabilizer of axonemal microtubules 1 |
| Synonyms | 4930500O09Rik, C9orf138, FAM154A, LOC100365211, LOC684579, stabilizer of axonemal microtubules 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SAXO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- basal bodies
- centriole
- axonemes
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SAXO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell projection organization
- cold acclimation
- protein stabilization
- positive regulation of flagellum assembly
- cellular response to cold
Cellular Component
Where in the cell the gene product is active
- centrosome
- motile cilium
- axonemal microtubule
- cytoskeleton
- centriole
- cilium basal body
- sperm flagellum
Molecular Function
What the gene product does at the molecular level
- protein binding
- microtubule binding