FHL3 Gene Summary [Human]
The protein encoded by this gene is a member of a family of proteins containing a four-and-a-half LIM domain, which is a highly conserved double zinc finger motif. The encoded protein has been shown to interact with the cancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal muscle myogenesis protein MyoD, and the high-affinity IgE beta chain regulator MZF-1. This protein may be involved in tumor suppression, repression of MyoD expression, and repression of IgE receptor expression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Processed Transcript |
| Official Symbol | FHL3 |
| Official Name | four and a half LIM domains 3 [Source:HGNC Symbol;Acc:HGNC:3704] |
| Ensembl ID | ENSG00000183386 |
| Bio databases IDs | |
| Aliases | four and a half LIM domains 3 |
| Synonyms | four and a half LIM domains 3, SLIM2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FHL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- half LIM domain
- actin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- amyotrophic lateral sclerosis
- breast cancer
- infection by HIV-1
role in cell
- disruption
- organization
- growth
- function in
- cell spreading
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- focal adhesions
- Nucleus
- I band
- m-bands
- Z line
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FHL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- Z disc
- nucleus
- focal adhesion
- stress fiber
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- actin binding
- metal ion binding