RAET1L Gene Summary [Human]
RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | RAET1L |
| Official Name | retinoic acid early transcript 1L [Source:HGNC Symbol;Acc:HGNC:16798] |
| Ensembl ID | ENSG00000155918 |
| Bio databases IDs | |
| Aliases | retinoic acid early transcript 1L |
| Synonyms | RAET1H, retinoic acid early transcript 1L, ULBP6 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RAET1L often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Class I Histocompatibility antigen, domains alpha 1 and 2
- protein binding
Pathways
Biological processes and signaling networks where the RAET1L gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- cell surface
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RAET1L gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- positive regulation of T cell mediated cytotoxicity
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib
Cellular Component
Where in the cell the gene product is active
- extracellular space
- intracellular membrane-bounded organelle
- external side of plasma membrane
- endoplasmic reticulum
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding