PAF1 Gene Summary [Human]
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | PAF1 |
| Official Name | PAF1 homolog, Paf1/RNA polymerase II complex component [Source:HGNC Symbol;Acc:HGNC:25459] |
| Ensembl ID | ENSG00000006712 |
| Bio databases IDs | |
| Aliases | PAF1 homolog, Paf1/RNA polymerase II complex component |
| Synonyms | 5730511K23RIK, F23149 1, PAF1 homolog, Paf1/RNA polymerase II complex component, Paf1, RNA polymerase II complex component, PD2, RGD1306219 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PAF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Paf1
- enzyme binding
- chromatin binding
- Serine-rich region of AP3B1, clathrin-adaptor complex
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- infection by Influenza A virus subtype H1N1
role in cell
- expression in
- differentiation
- migration
- cell death
- growth
- proliferation
- binding in
- recruitment in
- transactivation in
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PAF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- stem cell maintenance
- negative regulation of myeloid cell differentiation
- cellular response to lipopolysaccharide
- endodermal cell fate commitment
- mRNA 3'-end processing
- Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- protein localization to nucleus
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- Cdc73/Paf1 complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding
- RNA polymerase II core binding