ULBP2
ULBP2 Gene Summary
This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]
Details
| Type | Protein Coding |
| Official Symbol | ULBP2 |
| Official Name | UL16 binding protein 2 [Source:HGNC Symbol;Acc:HGNC:14894] |
| Ensembl ID | ENSG00000131015 |
| Bio databases IDs | |
| Aliases | UL16 binding protein 2 |
| Synonyms | ALCAN-alpha,ALCAN-α,N2DL2,NKG2DL2,RAET1H,RAET1L,UL16 binding protein 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- lipid binding
- natural killer cell lectin-like receptor binding
- binding protein
- alpha2 domain
- receptor agonist activity
- protein binding
- alpha1 domain
- transmembrane receptor
- phosphatidylinositol binding
Pathways
Biological processes and signaling networks where the ULBP2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- CGRRF1
- TMEM201
- HRAS
- TGOLN2
- miR-519a-3p (and other miRNAs w/seed AAGUGCA)
- TMEM30B
- SRC
- KLRK1
- HCST
disease
- colon adenocarcinoma
- colon epithelial cancer
regulated by
- OSM
- Staphylococcus aureus A9798
- Staphylococcus aureus A9781
- ERBB2
- spironolactone
- lipopolysaccharide
- IL32
- VPR
- IL15
- Enterotoxin B
regulates
- AKT
- TNF
- KLRK1
- JAK2
- MAPK3
- IFNG
- MAPK1
- CCL1
- ULBP1
- Integrin alpha L beta 2
role in cell
- expression in
- activation in
- activation
- binding
- proliferation
- lysis
- killing by
- degranulation
- killing
- cytotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- cell surface
- Extracellular Space
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the ULBP2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- immune response
- natural killer cell activation
- natural killer cell mediated cytotoxicity
- positive regulation of T cell mediated cytotoxicity
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular space
- intracellular membrane-bounded organelle
- external side of plasma membrane
- endoplasmic reticulum
- extracellular region
- plasma membrane
- cell surface
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- natural killer cell lectin-like receptor binding