SAMD8 Gene Summary [Human]
Predicted to enable ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Involved in ceramide biosynthetic process and regulation of ceramide biosynthetic process. Located in cytosol and endoplasmic reticulum. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SAMD8 |
| Official Name | sterile alpha motif domain containing 8 [Source:HGNC Symbol;Acc:HGNC:26320] |
| Ensembl ID | ENSG00000156671 |
| Bio databases IDs | |
| Aliases | sterile alpha motif domain containing 8, sphingomyelin synthase related, ceramide phosphoethanolamine synthase |
| Synonyms | 1110053F04RIK, 1700010P07RIK, HEL-177, SMSr, sterile alpha motif domain containing 8, sterile α motif domain containing 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SAMD8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- substituted phosphate group transferase
- SAM (Sterile alpha motif )
- PAP2 superfamily C-terminal
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SAMD8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ceramide biosynthetic process
- regulation of ceramide biosynthetic process
- sphingomyelin biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- cytosol
- Golgi membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ceramide cholinephosphotransferase activity
- sphingomyelin synthase activity