FABP5 Gene Summary [Human]
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | FABP5 |
| Official Name | fatty acid binding protein 5 [Source:HGNC Symbol;Acc:HGNC:3560] |
| Ensembl ID | ENSG00000164687 |
| Bio databases IDs | |
| Aliases | fatty acid binding protein 5 |
| Synonyms | C-FABP, DA11, E-FABP, Fabpe, Fabp epithelial, fatty acid binding protein 5, fatty acid binding protein 5, epidermal, KFABP, Klbp, mal1, PA-FABP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FABP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain fatty acid transporter
- lipid binding
- binding protein
- lipocalin/cytosolic fatty acid-binding protein family
- fatty acid binding
- protein binding
- retinoid binding
- identical protein binding
- Lipocalin / cytosolic fatty-acid binding protein family
- transporter
Pathways
Biological processes and signaling networks where the FABP5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- hepatocellular carcinoma
- liver cancer
- colorectal cancer
- nonalcoholic fatty liver disease
- metastasis
- epithelial cancer
- obesity
- papillomatosis
role in cell
- expression in
- cell viability
- proliferation
- quantity
- invasion by
- migration
- differentiation
- production in
- accumulation in
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- azurophil granule lumen
- organelle
- Extracellular Space
- Nucleus
- Plasma Membrane
- secretory granule membrane
- cytosol
- nucleoplasm
- nucleoli
- growth cone
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FABP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of glucose transport
- long-chain fatty acid transport
- fatty acid transport
- positive regulation of peroxisome proliferator activated receptor signaling pathway
- regulation of prostaglandin biosynthetic process
- lipid metabolic process
- glucose homeostasis
- epidermis development
- glucose metabolic process
- phosphatidylcholine biosynthetic process
- regulation of sensory perception of pain
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- secretory granule membrane
- nucleus
- extracellular vesicular exosome
- cytoplasm
- cytosol
- synapse
- extracellular region
- plasma membrane
- azurophil granule lumen
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- retinoic acid binding
- identical protein binding
- fatty acid binding
- protein binding
- lipid binding
- long-chain fatty acid transporter activity