KCNJ15
KCNJ15 Gene Summary
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Eight transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Feb 2013]
Details
| Type | Processed Transcript |
| Official Symbol | KCNJ15 |
| Official Name | potassium inwardly rectifying channel subfamily J member 15 [Source:HGNC Symbol;Acc:HGNC:6261] |
| Ensembl ID | ENSG00000157551 |
| Bio databases IDs | |
| Aliases | potassium inwardly rectifying channel subfamily J member 15 |
| Synonyms | 4930414N08Rik,AI182284,AI267127,IRKK,KIR1.3,KIR4.2,potassium inwardly rectifying channel subfamily J member 15,potassium inwardly-rectifying channel, subfamily J, member 15 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- potassium channel
- inward rectifier potassium channel
- cytoplasmic domain
- Inward rectifier potassium channel C-terminal domain
- Inward rectifier potassium channel transmembrane domain
- protein binding
- ion channel
Pathways
Biological processes and signaling networks where the KCNJ15 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- SNTA1
- IL16
- PATJ
- KCNJ2
- OSMR
- MYH9
- MYH10
- KCNJ5
disease
- rheumatoid arthritis
- acute myeloid leukemia
- peritonsillar abscess disorder
- renal clear cell adenocarcinoma
- renal clear cell cancer
regulated by
- lipopolysaccharide
- IL13
- dexamethasone
- TNF
- glycochenodeoxycholate
- glycodeoxycholic acid
- glycocholic acid
- taurochenodeoxycholate
- taurocholic acid
- taurodeoxycholic acid
regulates
- insulin
- K+
role in cell
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the KCNJ15 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- potassium ion transport
- regulation of ion transmembrane transport
CELLULAR COMPONENT
Where in the cell the gene product is active
- ion channel complex
- plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- protein binding
- inward rectifier potassium channel activity