OSMR
OSMR Gene Summary
This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Details
| Type | Protein Coding |
| Official Symbol | OSMR |
| Official Name | oncostatin M receptor [Source:HGNC Symbol;Acc:HGNC:8507] |
| Ensembl ID | ENSG00000145623 |
| Bio databases IDs | |
| Aliases | oncostatin M receptor, Oncostatin-M-specific receptor subunit beta |
| Synonyms | c12,IL-31RB,IL-31R-beta,IL-31R-β,oncostatin M receptor,OSMRB,OSMR beta,OSMR β,PLCA1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- STAT binding domain
- proline-rich box
- extracellular domain
- cytokine binding
- tyrosine activation motif
- protein binding
- phosphotyrosine binding domain
- Fibronectin type 3 domain
- Leukemia inhibitory factor receptor D2 domain
- YXXP domain
- cytoplasmic domain
- FN3
- oncostatin-M receptor
- transmembrane domain
- intracellular domain
- transmembrane receptor
- growth factor binding
Pathways
Biological processes and signaling networks where the OSMR gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- NEK4
- IL6ST
- HSPA9
- MRAP2
- OSM
- BMPR1A
- TYK2
- TRIM25
- FFAR1
- JAK1
disease
- angioimmunoblastic T-cell lymphoma
- epithelial cancer
- COVID-19
- insulin resistance
- inflammatory bowel disease
- ovarian cancer
- primary central nervous system lymphoma
- primary cancer
- lymphomagenesis
- central nervous system cancer
regulated by
- lipopolysaccharide
- EGFR
- IL17A
- TNF
- IL1B
- long-term hematopoietic stem cells
- Large T Antigen
- mir-122 (includes others)
- OSM
- RAF1
regulates
- CASP3
- ALB
- p38 MAPK
- TIMP1
- STAT3
- IL6
- collagen
- ERK1/2
- CCL2
- JNK
role in cell
- binding in
- migration
- proliferation
- expression in
- phosphorylation in
- growth
- accumulation
- apoptosis
- degeneration
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- plasma membrane extracellular face
- apical membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the OSMR gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- positive regulation of acute inflammatory response
- response to cytokine stimulus
- oncostatin-M-mediated signaling pathway
- cytokine-mediated signaling pathway
- positive regulation of cell proliferation
CELLULAR COMPONENT
Where in the cell the gene product is active
- oncostatin-M receptor complex
- external side of plasma membrane
- receptor complex
- plasma membrane
- apical plasma membrane
MOLECULAR FUNCTION
What the gene product does at the molecular level
- growth factor binding
- protein binding
- oncostatin-M receptor activity
- ciliary neurotrophic factor receptor binding
- cytokine receptor activity
- cytokine binding