ZNF618 Gene Summary [Human]
Enables identical protein binding activity and transcription coregulator binding activity. Involved in positive regulation of chromatin binding activity. Located in chromatin. Part of pericentric heterochromatin. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF618 |
| Official Name | zinc finger protein 618 [Source:HGNC Symbol;Acc:HGNC:29416] |
| Ensembl ID | ENSG00000157657 |
| Bio databases IDs | |
| Aliases | zinc finger protein 618, neural precursor cell expressed, developmentally down-regulated 10 |
| Synonyms | 2810031P15Rik, 2810040O04Rik, AI415580, bM257P7.1, D430033D05Rik, FP13169, KIAA1952, LOC286334, NEDD10, Zfp618, zinc finger protein 618 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF618 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- transcription factor binding
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centromeres
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF618 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of chromatin binding
- regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
- centromeric heterochromatin
Molecular Function
What the gene product does at the molecular level
- transcription cofactor binding
- DNA binding
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- metal ion binding