CSNK1A1 Gene Summary [Human]
Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CSNK1A1 |
| Official Name | casein kinase 1 alpha 1 [Source:HGNC Symbol;Acc:HGNC:2451] |
| Ensembl ID | ENSG00000113712 |
| Bio databases IDs | |
| Aliases | casein kinase 1 alpha 1, clock regulator kinase |
| Synonyms | 2610208K14Rik, 4632404G05Rik, 5430427P18RIK, CASEIN KINASE1 alpha, casein kinase 1 alpha 1, casein kinase 1, alpha 1, CASEIN KINASE1 α, casein kinase 1 α 1, casein kinase 1, α 1, Casein kinase-1, α-1 polypeptide, CK1, CK1a, CK1alpha, CK1α, CKIa, CKI-alpha, CKI-α, Csnk1a, HEL-S-77p, HLCDGP1, PRO2975 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CSNK1A1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- peptide binding
- protein kinase
- Protein Kinases, catalytic domain
- ATP-binding domain
- alcohol group acceptor phosphotransferase
- ATP binding
- phosphoprotein binding
- protein binding
- magnesium ion binding
Pathways
Biological processes and signaling networks where the CSNK1A1 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Gap Junction Signaling
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Role of NFAT in Regulation of the Immune Response
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- WNT/β-catenin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- neoplasia
- metastasis
- colorectal cancer
- dysplasia
- esophageal carcinoma
- esophageal carcinoma formation
- tumorigenesis
- primary melanoma
- melanoma cancer
role in cell
- expression in
- activation in
- morphology
- growth
- proliferation
- cell viability
- phosphorylation in
- apoptosis
- accumulation
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- spindle apparatus
- cilia
- perinuclear region
- basal bodies
- centrosome
- Golgi Apparatus
- cytosol
- nuclear speckles
- keratin intermediate filaments
- mitotic spindle
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CSNK1A1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- signal transduction
- cellular response to nutrient
- Golgi organization
- intermediate filament cytoskeleton organization
- cell surface receptor signaling pathway
- protein phosphorylation
- negative regulation of NLRP3 inflammasome complex assembly
- cell division
- negative regulation of canonical Wnt receptor signaling pathway
- viral protein processing
- proteasomal ubiquitin-dependent protein catabolic process
- Wnt receptor signaling pathway
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cilium basal body
- nuclear speck
- kinetochore
- beta-catenin destruction complex
- nucleus
- centrosome
- keratin filament
- cytoplasm
- mRNA cleavage and polyadenylation specificity factor complex
- membrane
- spindle
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein kinase activity
- protein serine/threonine kinase activity