VCAN Gene Summary [Human]
This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Details
| Type | Protein Coding |
| Official Symbol | VCAN |
| Official Name | versican [Source:HGNC Symbol;Acc:HGNC:2464] |
| Ensembl ID | ENSG00000038427 |
| Bio databases IDs | |
| Aliases | versican, versican proteoglycan |
| Synonyms | 5430420N07RIK, 9430051N09, CHONDROITIN SULFATE PROTEOGLYCAN, Chondroitin sulfate proteoglycan 2, CHONDROITIN sulphATE PROTEOGLYCAN, Chondroitin sulphate proteoglycan 2, CSPG2, DPEAAE, ERVR, GHAP, hdf, NG2, PG-M, PG-M(V0), PG-M(V1), Versican, Versican V1, Versican V2, WGN, WGN1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VCAN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- complement binding domain
- B loop
- carbohydrate recognition domain
- G1-domain
- low-density lipoprotein binding
- cleavage site
- cell cycle regulatory domain
- EGF_CA
- Immunoglobulin like
- membrane-proximal domain
- Immunoglobulin V-set domain
- SUSHI repeat
- lectin domain
- extracellular domain
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Immunoglobulin V-Type
- extracellular matrix structural constituent conferring compression resistance
- B' loop
- immunoglobulin domain
- protein phosphatase binding
- Human growth factor-like EGF
- central domain
- Extracellular link domain
- protein binding
- EGF-like domain
- glycosaminoglycan binding
- CCP
- alpha dystroglycan binding domain
- protein tyrosine phosphatase activator
- A loop
- Link_Domain
- neo-epitope
- glycosaminoglycan attachment site
- Lectin C-type domain
- EGF domain
- Sushi repeat (SCR repeat)
- hyaluronic acid binding
- G3 domain
- CBP binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colorectal cancer
- COVID-19
- head and neck squamous cell carcinoma
- hepatocellular carcinoma
- gastric adenocarcinoma
- breast cancer
- lung squamous cell carcinoma
- epithelial cancer
- gastric epithelial cancer
role in cell
- activation in
- expression in
- phosphorylation in
- apoptosis
- migration
- aggregation
- activation
- binding in
- invasion
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- soluble fraction
- membrane fraction
- Golgi lumen
- interterritorial matrix
- Cytoplasm
- cell surface
- cell borders
- Plasma Membrane
- endoplasmic reticulum lumen
- lysosomal compartment
- nodes of Ranvier
- synapse
- perinuclear vesicles
- microfibrils
- extracellular matrix
- perikaryon
- plasma
- perineuronal net
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VCAN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- skeletal system development
- osteoblast differentiation
- positive regulation of neuroblast proliferation
- cell recognition
- cell adhesion
- glial cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- interphotoreceptor matrix
- membrane
- perineuronal net
- lysosomal lumen
- extracellular matrix
- synapse
- extracellular region
- Golgi lumen
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- protein binding
- glycosaminoglycan binding
- calcium ion binding
- extracellular matrix structural constituent conferring compression resistance
- hyaluronic acid binding
- carbohydrate binding