KCNB1 Gene Summary [Human]
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier potassium channel and its activity is modulated by some other family members. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | KCNB1 |
| Official Name | potassium voltage-gated channel subfamily B member 1 [Source:HGNC Symbol;Acc:HGNC:6231] |
| Ensembl ID | ENSG00000158445 |
| Bio databases IDs | |
| Aliases | potassium voltage-gated channel subfamily B member 1 |
| Synonyms | DEE26, DRK1, DRK1PC, Kcr1-1, KV2.1, LOC100502627, potassium voltage gated channel, Shab-related subfamily, member 1, potassium voltage-gated channel subfamily B member 1, Shab |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KCNB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- NAB domain
- outward rectifier potassium channel
- delayed rectifier potassium channel
- Kv2 voltage-gated K+ channel
- Ion transport protein
- BTB_POZ
- protein binding
- ion channel
- voltage-gated potassium channel
- Broad-Complex, Tramtrack and Bric a brac
- ion channel binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- early infantile epileptic encephalopathy type 26
- rotator cuff injury
- mental retardation
- major depression
- schizophrenia
- uterine serous papillary cancer
- primary progressive multiple sclerosis
- Ohtahara syndrome
- bipolar disorder
role in cell
- apoptosis
- activation in
- cell death
- phosphorylation in
- migration
- docking
- development
- polarization
- motility
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cortical endoplasmic reticulum
- cell surface
- somatodendritic region
- perinuclear region
- cellular membrane
- apical membrane
- postsynaptic membrane
- synaptic membrane
- lateral plasma membrane
- dendrite initial segments
- synapse
- membrane rafts
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KCNB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- potassium ion transmembrane transport
- protein homooligomerization
- positive regulation of long term synaptic depression
- response to axon injury
- negative regulation of insulin secretion
- positive regulation of calcium ion-dependent exocytosis
- glutamate receptor signaling pathway
- clustering of voltage-gated potassium channels
- positive regulation of catecholamine secretion
- cellular response to nutrient levels
- cellular response to calcium ion
- cellular response to glucose stimulus
- glucose homeostasis
- vesicle docking involved in exocytosis
- regulation of action potential
- positive regulation of norepinephrine secretion
- regulation of motor neuron apoptotic process
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- dendrite membrane
- lateral plasma membrane
- voltage-gated potassium channel complex
- neuronal cell body membrane
- perikaryon
- plasma membrane
- cell surface
- dendrite
- perinuclear region of cytoplasm
- postsynaptic membrane
- sarcolemma
- axon
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- delayed rectifier potassium channel activity
- outward rectifier potassium channel activity
- SNARE binding
- ion channel binding