Kcnb1 Gene Summary [Mouse]
Enables delayed rectifier potassium channel activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of insulin secretion; and positive regulation of long-term synaptic depression. Located in dendrite and neuronal cell body membrane. Part of voltage-gated potassium channel complex. Is expressed in several structures, including adipose tissue; brain; cardiovascular system; genitourinary system; and gut. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 26 and epilepsy. Orthologous to human KCNB1 (potassium voltage-gated channel subfamily B member 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnb1 |
| Official Name | potassium voltage gated channel, Shab-related subfamily, member 1 [Source:MGI Symbol;Acc:MGI:96666] |
| Ensembl ID | ENSMUSG00000050556 |
| Bio databases IDs | |
| Aliases | potassium voltage gated channel, Shab-related subfamily, member 1 |
| Synonyms | DEE26, DRK1, DRK1PC, Kcr1-1, KV2.1, LOC100502627, potassium voltage gated channel, Shab-related subfamily, member 1, potassium voltage-gated channel subfamily B member 1, Shab |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- NAB domain
- outward rectifier potassium channel
- delayed rectifier potassium channel
- Kv2 voltage-gated K+ channel
- Ion transport protein
- BTB_POZ
- protein binding
- ion channel
- voltage-gated potassium channel
- Broad-Complex, Tramtrack and Bric a brac
- ion channel binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- early infantile epileptic encephalopathy type 26
- rotator cuff injury
- mental retardation
- major depression
- schizophrenia
- uterine serous papillary cancer
- primary progressive multiple sclerosis
- Ohtahara syndrome
- bipolar disorder
role in cell
- apoptosis
- activation in
- cell death
- phosphorylation in
- migration
- docking
- development
- polarization
- motility
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cortical endoplasmic reticulum
- cell surface
- somatodendritic region
- perinuclear region
- cellular membrane
- apical membrane
- postsynaptic membrane
- synaptic membrane
- lateral plasma membrane
- dendrite initial segments
- synapse
- membrane rafts
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- potassium ion transmembrane transport
- protein homooligomerization
- positive regulation of long term synaptic depression
- response to axon injury
- negative regulation of insulin secretion
- positive regulation of calcium ion-dependent exocytosis
- glutamate receptor signaling pathway
- clustering of voltage-gated potassium channels
- positive regulation of catecholamine secretion
- cellular response to nutrient levels
- cellular response to calcium ion
- cellular response to glucose stimulus
- glucose homeostasis
- vesicle docking involved in exocytosis
- regulation of action potential
- positive regulation of norepinephrine secretion
- regulation of motor neuron apoptotic process
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- dendrite membrane
- lateral plasma membrane
- voltage-gated potassium channel complex
- neuronal cell body membrane
- perikaryon
- plasma membrane
- cell surface
- dendrite
- perinuclear region of cytoplasm
- postsynaptic membrane
- sarcolemma
- axon
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- delayed rectifier potassium channel activity
- outward rectifier potassium channel activity
- SNARE binding
- ion channel binding