DYNC1I1 Gene Summary [Human]
Enables spectrin binding activity. Involved in vesicle transport along microtubule. Located in several cellular components, including kinetochore; recycling endosome; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DYNC1I1 |
| Official Name | dynein cytoplasmic 1 intermediate chain 1 [Source:HGNC Symbol;Acc:HGNC:2963] |
| Ensembl ID | ENSG00000158560 |
| Bio databases IDs | |
| Aliases | dynein cytoplasmic 1 intermediate chain 1 |
| Synonyms | DH IC-1, DIC, DNCI1, DNCIC1, Dynein, dynein cytoplasmic 1 intermediate chain 1, IC74 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DYNC1I1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- WD40 repeats
- WD domain, G-beta repeat
- spectrin binding
- dynein light chain binding
- WD40
- protein binding
- motor protein
- Cytoplasmic dynein 1 intermediate chain 2
- microtubule motor protein
Pathways
Biological processes and signaling networks where the DYNC1I1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- dementia
- osteoarthritis
- androgenic alopecia
- cancer
- rotator cuff injury
- Huntington disease
- glioblastoma
- glioblastoma cancer
- spinal stenosis
regulates
role in cell
- survival
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule aster fraction
- soluble fraction
- membrane fraction
- cytoplasmic ribonucleoprotein granule
- perinuclear region
- Nucleus
- vesicles
- Golgi Apparatus
- microtubules
- cytosol
- Golgi membrane
- spindle pole
- neurites
- recycling endosomes
- transport vesicles
- cellular protrusions
- kinetochores
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DYNC1I1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle transport along microtubule
- microtubule-based transport
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic dynein complex
- perinuclear region of cytoplasm
- cytoplasm
- spindle pole
- cytosol
- vesicle
- recycling endosome
- kinetochore
- microtubule
Molecular Function
What the gene product does at the molecular level
- microtubule motor activity
- protein binding
- spectrin binding
- dynein heavy chain binding
- dynein light chain binding
- microtubule binding
- motor activity