SPHK2 Gene Summary [Human]
This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | SPHK2 |
| Official Name | sphingosine kinase 2 [Source:HGNC Symbol;Acc:HGNC:18859] |
| Ensembl ID | ENSG00000063176 |
| Bio databases IDs | |
| Aliases | sphingosine kinase 2 |
| Synonyms | SK-2, sphingosine kinase 2, SPK-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPHK2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sphinganine kinase
- bioactive lipid receptor
- histone binding
- lipid kinase
- nuclear export signal
- D-erythro-sphingosine kinase
- Diacylglycerol kinase catalytic domain
- enzyme
- protein binding
- proline rich domain
- Diacylglycerol kinase catalytic domain (presumed)
Pathways
Biological processes and signaling networks where the SPHK2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
- hepatic steatosis
- COVID-19
- insulin resistance
- organismal death
- exencephaly
- psoriasis
- thrombocytopenia
- epileptiform activity
- collagen-induced arthritis
role in cell
- expression in
- invasion by
- migration
- apoptosis
- phosphorylation in
- molecular cleavage in
- cell death
- proliferation
- production in
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- endoplasmic reticulum/Golgi apparatus fractions
- intracellular membrane fractions
- membrane fraction
- Cytoplasm
- intracellular membranes
- cellular membrane
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- endoplasmic reticulum membrane
- Golgi membrane
- mitochondrial membrane
- mitochondrial inner membrane
- nucleosomes
- nucleoplasm
- mitoplasts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPHK2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- positive regulation of mast cell degranulation
- positive regulation of protein kinase C signaling cascade
- positive regulation of cell proliferation
- sphingosine biosynthetic process
- regulation of I-kappaB kinase/NF-kappaB cascade
- sphingosine-1-phosphate signaling pathway
- blood vessel development
- negative regulation of cell growth
- positive regulation of tumor necrosis factor production
- phosphorylation
- regulation of ATP biosynthetic process
- sphingolipid biosynthetic process
- positive regulation of gene expression, epigenetic
- sphingosine metabolic process
- brain development
- positive regulation of calcium ion import
- positive regulation of cytokine production involved in immune response
- sphinganine-1-phosphate biosynthetic process
- positive regulation of interleukin-13 production
- positive regulation of apoptotic process
- positive regulation of interleukin-6 production
- positive regulation of ceramide biosynthetic process
- positive regulation of mast cell activation involved in immune response
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- mitochondrion
- cytosol
- endoplasmic reticulum
- nucleosome
- mitochondrial inner membrane
- lysosomal membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sphinganine kinase activity
- sphingosine-1-phosphate receptor activity
- ATP binding
- D-erythro-sphingosine kinase activity
- protein binding
- histone binding
- lipid kinase activity
- small GTPase binding