YTHDF1 Gene Summary [Human]
Enables N6-methyladenosine-containing RNA binding activity and ribosome binding activity. Involved in mRNA destabilization; positive regulation of translational initiation; and stress granule assembly. Located in P-body and cytoplasmic stress granule. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | YTHDF1 |
| Official Name | YTH N6-methyladenosine RNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:15867] |
| Ensembl ID | ENSG00000149658 |
| Bio databases IDs | |
| Aliases | YTH N6-methyladenosine RNA binding protein 1 |
| Synonyms | 2210410K23Rik, 8030473O16, C20orf21, Daca1 homolog, DF1, YTH N6-methyladenosine RNA binding protein 1, YTH N6-methyladenosine RNA binding protein F1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human YTHDF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EVE and YTH domains belong to the PUA superfamily
- protein binding activity, bridging
- ribosome binding
- protein binding
- YT521-B-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- pancreatic cancer
- impaired glucose tolerance
- cervical cancer
- colorectal cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- acute liver failure
- renal fibrosis
- diffuse large B-cell lymphoma
role in cell
- proliferation
- apoptosis
- downregulation in
- growth
- morphology
- expression in
- cell viability
- migration
- invasion by
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- Nucleus
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human YTHDF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translational initiation
- stress granule assembly
- regulation of antigen processing and presentation
- mRNA destabilization
- positive regulation of translation
- organelle assembly
- regulation of long-term synaptic potentiation
- regulation of mRNA stability
- learning
- memory
- immune system process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- cytoplasm
- cytoplasmic mRNA processing body
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- ribosome binding
- mRNA binding