TMED4 Gene Summary [Human]
Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TMED4 |
| Official Name | transmembrane p24 trafficking protein 4 [Source:HGNC Symbol;Acc:HGNC:22301] |
| Ensembl ID | ENSG00000158604 |
| Bio databases IDs | |
| Aliases | transmembrane p24 trafficking protein 4 |
| Synonyms | 1110014L17Rik, EMP24, ERS25, GMP25iso, HNLF, p24a3, P24-alpha-2, p24alpha3, P24-α-2, RGD1306319, TRANSMEMBRANE EMP24 protein TRANSPORT domain containing 4, transmembrane p24 trafficking protein 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TMED4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- emp24/gp25L/p24 family/GOLD
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TMED4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- Golgi organization
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi apparatus
- ER to Golgi transport vesicle
- endoplasmic reticulum
- endoplasmic reticulum-Golgi intermediate compartment
Molecular Function
What the gene product does at the molecular level
- cargo receptor activity