IL13RA2 Gene Summary [Human]
The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | IL13RA2 |
| Official Name | interleukin 13 receptor subunit alpha 2 [Source:HGNC Symbol;Acc:HGNC:5975] |
| Ensembl ID | ENSG00000123496 |
| Bio databases IDs | |
| Aliases | interleukin 13 receptor subunit alpha 2, cancer/testis antigen 19 |
| Synonyms | CD213A2, CT19, IL13BP, IL-13R, IL-13R-alpha-2, IL-13R-α-2, interleukin 13 receptor, alpha 2, interleukin 13 receptor subunit alpha 2, interleukin 13 receptor subunit α 2, interleukin 13 receptor, α 2, LOC100361488 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL13RA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- FN3
- transmembrane domain
- extracellular ligand binding domain
- intracellular domain
- protein binding
- cytokine receptor
- transmembrane receptor
Pathways
Biological processes and signaling networks where the IL13RA2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diarrhea
- colorectal cancer
- glioblastoma
- colitis
- irritation
- airway hyperresponsiveness
- fibrosis
- cutaneous T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
role in cell
- proliferation
- expression in
- differentiation
- growth
- phosphorylation in
- number
- migration
- function
- invasion by
- abnormality
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- intracellular space
- cellular membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL13RA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokine-mediated signaling pathway
- negative regulation of immunoglobulin production
- immunoglobulin mediated immune response
- negative regulation of mast cell degranulation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- receptor complex
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- cytokine binding
- cytokine receptor activity