CFAP298 Gene Summary [Human]
This gene encodes a protein that plays a critical role in dynein arm assembly and motile cilia function. Mutations in this gene result in primary ciliary dyskinesia. Naturally occuring readthrough transcription occurs from this locus to the downstream t-complex 10 like (TCP10L) gene. [provided by RefSeq, Apr 2017]
Details
| Type | Protein Coding |
| Official Symbol | CFAP298 |
| Official Name | cilia and flagella associated protein 298 [Source:HGNC Symbol;Acc:HGNC:1301] |
| Ensembl ID | ENSG00000159079 |
| Bio databases IDs | |
| Aliases | cilia and flagella associated protein 298, kurly homolog (zebrafish), dynein axonemal assembly factor 16 |
| Synonyms | 1110004E09Rik, C21orf48, C21orf59, CILD26, cilia and flagella associated protein 298, cilia and flagella associate protien 298, DNAAF16, FBB18, Kur, RGD1306954 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CFAP298 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cilia- and flagella-associated protein 298
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- basal bodies
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CFAP298 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- regulation of cilium movement
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding