SERPINB8 Gene Summary [Human]
The protein encoded by this gene is a member of the ov-serpin family of serine protease inhibitors. The encoded protein is produced by platelets and can bind to and inhibit the function of furin, a serine protease involved in platelet functions. In addition, this protein has been found to enhance the mechanical stability of cell-cell adhesion in the skin, and defects in this gene have been associated with an autosomal-recessive form of exfoliative ichthyosis. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | SERPINB8 |
| Official Name | serpin family B member 8 [Source:HGNC Symbol;Acc:HGNC:8952] |
| Ensembl ID | ENSG00000166401 |
| Bio databases IDs | |
| Aliases | serpin family B member 8, cytoplasmic antiproteinase 2 |
| Synonyms | C18orf53, CAP-2, PI-8, PROTEINASE INHIBITOR 8, PSS5, serpin family B member 8 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINB8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein binding
- Serpin (serine protease inhibitor)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peeling skin syndrome 5
- uterine serous papillary cancer
- psoriasis
- vertigo
role in cell
- expression in
- proliferation
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINB8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell-cell adhesion
- negative regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding