PLXNB1 Gene Summary [Human]
Enables semaphorin receptor activity. Involved in several processes, including negative regulation of cell adhesion; regulation of cell shape; and semaphorin-plexin signaling pathway. Is integral component of plasma membrane. Part of semaphorin receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLXNB1 |
| Official Name | plexin B1 [Source:HGNC Symbol;Acc:HGNC:9103] |
| Ensembl ID | ENSG00000164050 |
| Bio databases IDs | |
| Aliases | plexin B1 |
| Synonyms | 2900002G15Rik, LOC102555419, mKIAA0407, PLEXIN-B1, PLXN5, SEP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLXNB1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- Plexin repeat
- IPT
- Plexin cytoplasmic RasGAP domain
- GTPase activator
- protein binding
- GTPase Activating Protein domain
- TIG domain
- Ras GTPase Activating Domain
- semaphorin domain
- Plexin cytoplasmic RhoGTPase-binding domain
- semaphorin receptor binding
- cytoplasmic domain
- TIG domain found in plexin
- IPT/TIG domain
- intracellular domain
- semaphorin receptor
- tail domain
- PDZ binding motif
- plexin/semaphorin/integrin domain
- Sema domain
- transmembrane receptor
- The Sema domain, a protein interacting module, of semaphorins and plexins
Pathways
Biological processes and signaling networks where the PLXNB1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial neoplasia
- primary prostate cancer
- liver cancer
- epithelial cancer
- hepatocellular carcinoma
- basal cell skin cancer
- skin neoplasia
- skin cancer
- osteosclerosis
role in cell
- expression in
- phosphorylation in
- invasion
- proliferation
- migration
- growth
- development
- formation
- organization
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cell surface
- Extracellular Space
- cellular membrane
- postsynaptic membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLXNB1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of Rho protein signal transduction
- negative regulation of cell adhesion
- neuron projection morphogenesis
- positive regulation of GTPase activity
- ossification involved in bone maturation
- positive regulation of axonogenesis
- regulation of cytoskeleton organization
- regulation of GTPase activity
- regulation of cell migration
- cell migration
- intracellular signal transduction
- positive regulation of protein kinase B signaling cascade
- negative regulation of osteoblast proliferation
- semaphorin-plexin signaling pathway
Cellular Component
Where in the cell the gene product is active
- semaphorin receptor complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- transmembrane signaling receptor activity
- GTPase activator activity
- semaphorin receptor activity
- GTPase activating protein binding
- semaphorin receptor binding