CLIC6 Gene Summary [Human]
This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | CLIC6 |
| Official Name | chloride intracellular channel 6 [Source:HGNC Symbol;Acc:HGNC:2065] |
| Ensembl ID | ENSG00000159212 |
| Bio databases IDs | |
| Aliases | chloride intracellular channel 6 |
| Synonyms | 5730466J16RIK, chloride intracellular channel 6, CLIC1L, CLIC6B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLIC6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutathione S-transferase, C-terminal domain
- Glutathione S-transferase, N-terminal domain
- C-terminal, alpha helical domain of the Glutathione S-transferase family
- G-protein-coupled receptor binding
- chloride channel
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- identical protein binding
- intracellular chloride channel protein
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- gastric adenocarcinoma
- gastric epithelial cancer
- ovarian carcinoma
- epithelial ovarian cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLIC6 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- extracellular vesicular exosome
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- D2 dopamine receptor binding
- D3 dopamine receptor binding
- D4 dopamine receptor binding
- chloride channel activity